NPR2 and achondroplasia: Based on this research, we started performing translational research on the activation of the CNP/NPR-B system to restore skeletal impairment, and previously reported the efficacy of the activation of the CNP/NPR-B system on a mouse model of achondroplasia by using a transgenic approach or intravenous injection of synthetic CNP-22, one molecular form of CNP20,34.