CCR2 and colitis: To unravel this problem, we prepared BM chimeric mice (chimeras) generated from enhanced green fluorescent protein (EGFP)-transgenic mice (EGFP mice) or CCR2-deficient (CCR2RFP/RFP) mice and analysed which subset of CCR2+ monocyte-derived cells was capable of acquiring fibrotic characteristics during the development of colon fibrosis in an azoxymethane (AOM)/dextran sodium sulphate (DSS) colitis model.