To provide further evidence of the significance of these novel data, future investigations will be need to assess the impact of HSC-specific overexpression of miR-25 in models of hepatic fibrosis in vivo, to fully evaluate the role of miR-25 on the Notch/TGFβ1-signaling pathway cross-talk that drives HSC collagen expression in chronic liver disease. The gene discussed is TGFB1; the disease is Hepatic fibrosis.