Since the systemic effects of exogenously administered apelin in preeclampsia are not well described, the goal of this study was to determine the effects of a systemically administrated and more stable form of apelin, (Pyr1)-apelin-13, on maternal and fetal characteristics, and cardiovascular and renal outcomes in an established rat model with preeclamptic features (TGA-PE, female transgenic for human angiotensinogen mated to male transgenic for human renin). This evidence concerns the gene APLN and preeclampsia.