To dissect the molecular mechanism of how Enz induces lncRNA-p21 to promote NED in PCa, we focused on investigating the EZH2, the key player of the PRC2 complex, since a recent study suggested that lncRNA-p21 could regulate PRC2 target genes expression17 and EZH2 was found to play key roles for NEPC progression25. The gene discussed is EZH2; the disease is posterior cortical atrophy.