To address our hypothesis, we performed glucose uptake assays and found that SNHG1 downregulation suppressed glucose uptake in glioma cells and attenuated the expression of genes involved in glucose metabolism, including HK2 and GLUT1 ((Fig. 2b–e), whereas the upregulation of SNHG1 showed the opposite results (Fig. 3a–e). Here, HK2 is linked to central nervous system cancer.