ENG and preeclampsia: In a transgenic mouse model overexpressing the transcription factor Storkhead box 1 (STOX1) gene, pregnant females develop typical human preeclampsia manifestations such as gestational hypertension, proteinuria, kidney and placental tissue alterations, reduced litter size, and increased plasma levels of the anti-angiogenic factors soluble fms-like tyrosine kinase 1 (s-Flt1) and soluble endoglin (sEng)21.