MCU and myopathy: However, while the initial outcome of genetic DRP1 ablation is identical to its overexpression, i.e., muscle atrophy via FoxO, our loss-of-function study also reveals the appearance of center-nucleated fibers, a sign of myopathy, and the involvement of different signaling pathways, including MCU upregulation, ER-stress, UPR activation, and great FGF21 induction (Fig. 8).