Interestingly, one of CD147 binders, YIPF2, was found to be a Rab-GDF recruiting and activating Rab5/Rab22a on ER-Golgi, promoting endocytosis, recycling, and secretion of CD147, and thus enhancing the malignant phenotypes of HCC cells. This evidence concerns the gene PAEP and hepatocellular carcinoma.