YIPF2 and hepatocellular carcinoma: As glycosyltransferases cannot work without integrated ER/Golgi morphology and YIPF2 interference hinders intracellular glycan synthesis41, it is logical that LG- and HG-CD147 are reduced in ER-Golgi fractions from YIPF2-KD HCC cells (Fig. 4c–f).