Although regarded as a paracrine hormone involved in embryonic development, wound healing, neurogenesis, and mitogenesis, fibroblast growth factor 1 (FGF1) has recently been found to be an efficient insulin sensitizer for the alleviation of type 2 diabetes mellitus and an important factor for maintaining the normal function of adipose tissue and metabolic homeostasis16,17. This evidence concerns the gene FGF1 and diabetes mellitus.