CDKN2B and neoplasm: For example, ANRIL could not only interact with SUZ12 (a subunit of the PRC2) and recruit the complex to inhibit the expression of p15 (INK4B), a well-known tumor suppressor gene [8,43,44], but also work in concert with other epigenetic regulators, such as p300 (a histone acetylator), and EZH2 (a histone methyltransferase component of the PRC2 complex) [45,46].