Interestingly, only a 25-fold increase in the miR-155 level could be induced in the unedited HP8-Cas9 cells compared to a 6,026-fold increase in miR-M4-deleted clone C48, suggesting that the absence of miR-M4 significantly enhances the ability of v-rel to induce miR-155 expression in MDV tumor cell lines. This evidence concerns the gene REL and neoplasm.