ZDHHC15 is one of a number of genes on the X chromosome that is duplicated in patients with intellectual disability (Linhares et al., 2016; Martinez et al., 2014), and one report has identified the loss of a ZDHHC15 transcript in a female patient with non-syndromic X-linked intellectual disability (Mansouri et al., 2005). The gene discussed is ZDHHC15; the disease is X-linked intellectual disability.