The main limitations of the present study is the lack of information on clinical variables reflecting HF and diabetes severity including ejection fraction, NYHA class and smoking status, vital parameters e.g. heart rate and blood pressure, body mass index, biochemical parameters such as natriuretic peptides (e.g. NT-pro-BNP), glucose levels, hemoglobin A1c and type of diabetes. Here, NPPB is linked to hydrops fetalis.