In contrast, there are reports showing the downregulation of pCREB in PAH PASMCs and the protective role of CREB from proliferation and remolding by regulating phosphatase and tension homolog (PTEN), a tumor suppressor gene, and mitochondrial calcium uniporter (MCU), a mitochondrial calcium uptake protein that can decrease [Ca2+]i [36,37]. The gene discussed is CREB1; the disease is pulmonary arterial hypertension.