Ultimately, the TRPV1/Ca2+/CaN/NFAT/Bal-2(TSLP, IL-2, α-actin) pathway, the TRPV1/Ca2+/CaN/CREB pathway and the TRPV1/Ca2+/c-jun(c-fos) pathway may be imprecise and sectional signaling pathways in the process of PAH. The gene discussed is NUP214; the disease is pulmonary arterial hypertension.