We have recently generated and described two mouse models of SCLC, overexpressing Mycl and Nfib (Huijbers et al., 2014, Semenova et al., 2016), following our finding that Mycl and Nfib oncogenes are frequently amplified and/or overexpressed in RP mouse tumors (RPM and RPF mice, respectively). The gene discussed is MYCL; the disease is small cell lung carcinoma.