We have recently generated and described two mouse models of SCLC, overexpressing Mycl and Nfib (Huijbers et al., 2014, Semenova et al., 2016), following our finding that Mycl and Nfib oncogenes are frequently amplified and/or overexpressed in RP mouse tumors (RPM and RPF mice, respectively). This evidence concerns the gene NFIB and small cell lung carcinoma.