Our laboratory has established several mouse models of SCLC, including Rb1/Trp53 (RP, control, Rb1flox/flox;Trp53flox/flox), Rb1/Trp53/Mycl (RPM, Rb1flox/flox;Trp53flox/flox;CAG < Lox66Mycl-LucLox71 >), and Rb1/Trp53/Nfib (RPF, Rb1flox/flox;Trp53flox/flox;CAG < Lox66Nfib-LucLox71 >). The gene discussed is NFIB; the disease is small cell lung carcinoma.