A number of laboratories have developed additional models in which tumor development is driven by deletion of other relevant tumor suppressors, such as Pten and Rbl2, or by the expression of other oncogenes, such as Mycl, cMyc, and Nfib (Mollaoglu et al., 2017, Semenova et al., 2016, Wu et al., 2016). This evidence concerns the gene PTEN and neoplasm.