Transthoracic echocardiography was normal.Patient, her sister and father have molecularly confirmed CFNS and both haveheterozygous missense mutation (c.451G > A; Gly151Ser) in exon 3 of EFNB1 gene.She has undergone surgery for frontonasal dysplasia. Here, EFNB1 is linked to craniofrontonasal syndrome.