Inflammation is mediated by the upregulation of NF-κB expression by OS,AGEs and TNF-α, which controls the immune response by stimulating geneticexpression of pro-inflammatory cytokines, adhesion molecules, NOS, cellproliferation and progression of the inflammatory cycle and OS.77,78 ROS and the AGE-RAGE interaction, stimulated byDM-related hyperglycemia, act as mediators of the multiprotein complexinflammasome Nlrp, which regulates the cleavage of pro-inflammatory cytokinesfrom the mature, active forms into innate immune cells, renal endothelial cells,glomerular cells and podocytes.79 The gene discussed is TNF; the disease is Hyperglycemia.