SOD1 and Hyperglycemia: The overproduction of RON induced by hyperglycemia reduces the expression ofantioxidant enzymes, including the superoxide dismutase (SOD) (particularly themanganese SOD subtype that acts in the mitochondria), thioredoxin reductase, andcatalase (CAT), and decreases regeneration of reduced glutathione (GSH) byactivation of the polyol pathway.