The PRF1 c.900C > T C/T genotype was more frequent among HIV- compared to HIV+ children, and was associated with decreased risk of acquiring HIV-1 infection (p=0.03, OR=0.47, CI=0.23-0.94; power=0.68; Table 1 and Table S1) also after adjustment for maternal CD4 cells count and HIV-1 plasma viral load (p=0.01, OR=0.40, CI=0.19-0.81; data not shown). This evidence concerns the gene PRF1 and HIV-1 infection.