We identified SNVs in MLL3,ARID2 and ALK. Mutations in MLL and ARID genefamilies have been previously documented for HNSCC (India Project Team of the International Cancer Genome Consortium, 2013;Martin et al., 2014).The ALK gene encodes yet another receptor tyrosine kinase, whichhas been found to be aberrantly expressed in several tumours, including anaplasticlarge cell lymphomas (Chiarle etal., 2008; Salaverriaet al., 2008), neuroblastoma (Lasorsa et al., 2016; Theruvath et al., 2016; Ueda et al., 2016) and non-small cell lungcancer (Soda et al., 2007;Quere et al., 2016). This evidence concerns the gene KMT2A and head and neck squamous cell carcinoma.