An IGF2BP3 mutation was found in a sample that also had drivermutations in PIK3CA and TP53. The protein productof IGF2BP3 is an RNA-binding factor that promotes cancer invasionby binding to transcripts that encode proteins, such as CD44, for functions relatedto cell migration, proliferation and adhesion (Ennajdaoui et al., 2016). The gene discussed is TP53; the disease is cancer.