The present study has the strength of including a large sample of a Mexican-Mestizopopulation without familial or personal antecedents of CAD or AVC that could biasthe results of the analysis of the gene LPA polymorphisms, theprevalence of high Lp(a), or the presence of coronary or aortic valve calcification.To avoid inaccuracy in determining Lp(a) concentrations due to differences in apo(a)molecular mass, Lp(a) was determined through immunonephelometry with polyclonalantibodies that allow identifying both small and large isoforms of apo(a) (Marcovina et al., 2000). Here, LPA is linked to coronary artery disorder.