CD8+ T-cells in tumors from WT and BATF3-deficient mice did not differ in terms of their CD69 expression (Fig 3G); there were however much fewer cytokine-expressing CD8+ T-cells detectable in tumors of BATF3-/- relative to WT mice, as assessed both upon re-stimulation with PMA/ionomycin, as well as with MC38 tumor antigen-derived peptide (Fig 3H and 3I, S3E Fig). Here, BATF3 is linked to neoplasm.