For instance, miR-199a-5p is known to inhibits VEGF-induced tumorigenesis [67] and suppresses human bladder cancer cell metastasis by targeting C-C chemokine receptor type 7 (CCR7) [68]; this miRNA is also documented to target ETS-1 and suppresses HMEC angiogenesis by inhibiting VEGF and HGF signaling [29]. This evidence concerns the gene HGF and urinary bladder carcinoma.