For instance, miR-199a-3p was previously reported to be downregulated and associated with impaired microvascular function in the retina of rats with diabetic retinopathy [50] and with anti-inflammatory properties including IKK/NF-κB/IL-8 [31] and COX-2 signaling suppression [32]. This evidence concerns the gene NFKB1 and diabetic retinopathy.