These increases in tumor glucose oxidation correlated with accelerated cell division in response to insulin: whereas there was no difference in cell division whether or not melanoma, small cell lung cancer, or B cell lymphoma cells were incubated in insulin, the three obesity-associated tumor types each showed a dose-dependent increase in cell division with insulin (Fig 4A, S2B Fig). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.