AKT1 and gastric cancer: It is well known that the PI3K/AKT signaling is critical for the proliferation, apoptosis, transformation, chemotherapy resistance and other processes in numerous malignancies, including GC.17, 18 Moreover, the IGF‐1/IGF1R pathway has been reported to be highly activated in the mesenchymal phenotype of GC characterized by a poor prognosis and resistance to chemotherapy compared with the epithelial phenotype.19 Given that the IGF‐1/PI3K/AKT pathway is crucial for GC carcinogenesis and progression, STIL‐targeted strategy may be promising for treatment of GC.