AKT1 and psoriasis: Preclinical studies [14] showed that icotinib hydrochloride could specifically inhibit EGFR tyrosine kinase and block the activation of downstream signaling pathways of Stat3 and Akt, regulating the proliferation and differentiation of keratinocytes and inhibiting angiogenesis and further improving the pathological conditions of epidermal keratosis and fine epidermis in psoriasis.