AFP and hepatitis B virus infection: Similarly, Plasma hsa_circ_0001445 also had a higher diagnostic accuracy than AFP for distinguishing HCC patients from healthy people or patients with hepatitis B. And when combined, the efficiency in distinguishing HCC from healthy controls (AUC: 0.970, 95% CI: 0.949–0.991), from cases of cirrhosis (AUC: 0.743, 95% CI: 0.664–0.821), or from cases of hepatitis B (AUC: 0.877, 95% CI: 0.817–0.938) was higher [22].