For instance, circSMAD2 inhibits the migration, invasion, and EMT of HCC cells by targeting miR-629 [23] and markedly associates with the differentiation degree; circC3P1 acts as a tumor suppressor via enhancing PCK1 expression by sponging miR-4641 to inhibit HCC growth and metastasis. The gene discussed is PCK1; the disease is neoplasm.