The balance between proinflammatory (IL-1β, IL-6 IL-12, IL-18, IL-17, or IL-23) and anti-inflammatory cytokines (IL-4, IL-10) is tightly regulated and directly involved in CVDs, not only in HTN development per se, but also in mediating hypertensive end-organ damage such as ventricular remodeling and renal and cerebral involvement [20, 49]. Here, IL18 is linked to hypertensive disorder.