Conversely, Jackhete et al. found that MVI was not associated with multilobar involvement in HCC, alpha fetoprotein (AFP) level, or the tumor differentiation [25] while Haung et al. found in a large cohort study that the MVI was associated with AFP>200, tumor encapsulation, tumor differentiation, and tumor size (>5cm) but no association was found with the gender, age, or etiology of the cirrhosis [26]. The gene discussed is AFP; the disease is hepatocellular carcinoma.