These genes included CEBPB, BCL2, PAN2, NOS3, FTL, ARHGEF37, SMC3, EP300, JAK2, RPS6KA3, RPS6KA1, PRKACA, HIPK1, HIPK2, MAPK8, GSK3A, CLK2, and CDK3. It indicates that these CTS transcriptional signatures could be biomarkers for colon cancer relapse. Here, HIPK2 is linked to colonic neoplasm.