These genes included CEBPB, BCL2, PAN2, NOS3, FTL, ARHGEF37, SMC3, EP300, JAK2, RPS6KA3, RPS6KA1, PRKACA, HIPK1, HIPK2, MAPK8, GSK3A, CLK2, and CDK3. It indicates that these CTS transcriptional signatures could be biomarkers for colon cancer relapse. Here, HIPK1 is linked to malignant colon neoplasm.