In addition, we found that CD8+ T cells had significantly higher enrichment levels in CTS versus colon normal stroma (Student's t-test, p=0.016), as well as in the high-stroma-content colon cancers versus the low-stroma-content colon cancers (Student's t-test, p=3.3∗10−8). This evidence concerns the gene CD8A and malignant colon neoplasm.