Among the upstream regulators (TFs, kinases, and MMTRs) of the DEGs, the expression of STAT3, RPS6KA5, IKBKE, ERBB2, MTOR, and NFKB1 had a positive correlation with OS in colon cancer, while the expression of CDK1, CDK5, and BRD2 had a negative correlation with OS in colon cancer (Figure 6(a)). The gene discussed is IKBKE; the disease is malignant colon neoplasm.