RUNX2 and hydrops fetalis: Among genes harboring an excess of HF SNCs associated with specific facial features, we find RUNX2, EDAR, and GLI3133, NFATC1134, SPOP135, DDR2136 and NELL1137, possibly carrying changes in regulatory regions, while mutations in the HHMC-carrying gene encoding for the transcription factor ATRX cause facial dysmorphism138.