PLEKHG1 and early-onset autosomal dominant Alzheimer disease: Finally, in the broader context of traits potentially related to cognition, we find an enrichment of HHMCs in genes associated to “Alzheimer’s disease (cognitive decline)” and “Cognitive decline (age-related)”, with seven associated genes (COX7B2, BCAS3, DMXL1, LIPC, PLEKHG1, TTLL2 and VIT).