In order to evaluate the effect of the tumor-derived exosomes on monocytes, purified CD14+ cells were incubated with 5 × 108 exosomes and the production of inflammatory proteins (sE-Selectin, GM-CSF, IFNα, IFNγ, IL-1α, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-17A/CTLA-8, IP-10/CXCL10, MCP-1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, sP-Selectin, TNFα) were analyzed on cell supernatants by multiplex ELISA. This evidence concerns the gene IL4 and neoplasm.