SW480- and U87-MG-derived exosomes induce the release of IL-1α (Fig. 5A), IL-8 (Fig. 5E) and MCP-1 (Fig. 5G) by monocytes, while exosomes released from all tumor cell lines after LPS treatment trigger the production of IL1β (Fig. 5B), IL-10 (Fig. 5C), IL-6 (Fig. 5D), MIP-1α (Fig. 5H), MIP-1β (Fig. 5I) and TNF-α (Fig. 5L) cytokines. This evidence concerns the gene CCL4 and neoplasm.