In addition, immunohistochemistry analysis revealed that GQ1b infusion increases BDNF expression in both the CA3 and dentate gyrus regions compared to aCSF-infused 3xTg-AD mice (CA3, WT + aCSF: 106.18 ± 3.86, AD + aCSF: 40.99 ± 25.38, AD + GQ1b: 83.62 ± 21.67; dentate gyrus, WT + aCSF: 133.40 ± 6.72, AD + aCSF: 78.18 ± 19.20, AD + GQ1b: 117.93 ± 5.77) (Fig. 3B,C). The gene discussed is BDNF; the disease is Alzheimer disease.