Enzyme-linked immunosorbent assays (ELISA) also demonstrated a significant elevation of hippocampal BDNF levels in GQ1b- versus aCSF-infused 3xTg-AD mice (AD + aCSF: 127.59 ± 6.17 pg/ml, AD + GQ1b: 174.89 ± 9.01 pg/ml) (Supplementary Fig. 4). The gene discussed is BDNF; the disease is Alzheimer disease.