Potential mechanisms by which induction of RAS pathway may contribute to metabolic dysfunction in obesity through ER stress include (a) Over activation of the RAS pathway induces ER stress which could upregulate levels of its resident protein SREBP;57 This would further induce its downstream targets including SREBP1c, which in part activates fatty acid synthesis leading to lipid accumulation and obesity58. The gene discussed is SREBF1; the disease is obesity due to melanocortin 4 receptor deficiency.