Interestingly, we found potential target genes, including DKK1, Hoxc13, DSG4, Wnt10A, FOXE1, SFRP1, and SFRP2 were overlapped with mRNAs, and enriched in the HF developmental pathways mentioned above, and were found to play important roles in HF development and morphogenesis68–74. Here, SFRP1 is linked to hydrops fetalis.