ENPP2 and pancreatic serous cystadenoma: A key observation in the present study is that we show in two independent cohorts of in total 252 large-duct PSC patients that high autotaxin activity is associated with reduced liver transplant-free survival with a moderate HR of 2.0 in multivariable regression, corroborating a previous finding by Wunsch et al., who investigated autotaxin in 115 PSC patients14.