Many of the predicted transcription factors have a known role in hematopoiesis and leukemia development (Ikzf2, Pbx3, and Hoxa13 for upregulated genes and Fos, Nkx2-2, Gata2 for downregulated genes, Supplementary Data 3 and 4, Fig. 2c, d). Here, NKX2-2 is linked to leukemia.