IKZF2 and acute lymphoblastic leukemia: Ikzf2 (Helios), a predicted regulator of upregulated transcripts, was itself overexpressed at the mRNA and protein levels, as confirmed by immunoblots in RPL10 R98S Ba/F3 cells, as well as in Jurkat T-ALL cells in which the RPL10 R98S mutation was introduced using CRISPR-Cas9 technology (Fig. 2e).