In the reactive astrocytes from the tumor we identified an increased expression of immune associated genes such as CHI3L1, HLA-DRA, CD274, HLA-DRB3, CD37 (Fig. 1b), as well as genes that contributed to proliferation (MKI67, ANXA2) and complement components (C1S, C1R) (Fig. 1b and Supplementary Fig. 2). This evidence concerns the gene ANXA2 and neoplasm.