Subsequently, our results indicate that a distinct reactive astrocytic subtype is mediated by a joint alteration of the surrounding secretome caused by both the tumor and microglia and that only in their presence, high concentrations of anti-inflammatory IL10 and TGFβ are detectable in the tumor microenvironment, which contributes substantially to the properties of an immunological “cold”-tumor environment. The gene discussed is TGFB1; the disease is neoplasm.