Indeed, the proportion of −/− progenitor cells was inversely correlated with the proportion of MSCA1+ subset in SCAT, while it was inversely correlated with −/CD271+ myofibroblast precursors in VSAT (Fig. 8b), suggesting that with obesity, the progenitor cells were preferentially oriented toward adipogenesis in SCAT and myofibroblast in VSAT. The gene discussed is NGFR; the disease is obesity due to melanocortin 4 receptor deficiency.