TP53 and triple-negative breast carcinoma: Olaparib dose–response curves for TP53 mutant triple negative breast cancer (TNBC) MDA-MB-231 cells41 revealed a concentration-dependent inhibition of cell proliferation that was in a IC50-intermediate range when compared to HGSOC cells (Fig. 6a, IC50: 2.92 ± 0.17 μM).