MYCN and hepatocellular carcinoma: To explore the regulating mechanisms of ATO on MCM7 expression in HCC cells, we analyzed the possible transcription factors regulating MCM7. It is predicted that four transcription factors including peroxisome proliferator-activated receptor gamma (PPAR-γ), N-Myc, SRF, and c-Myc have the putative binding sites on MCM7 promoter (Fig. 8a).