IRF1 and gastric cancer: By systematically coupling bioinformatics analyses, in vitro and in vivo experiments, and clinical sample data, we elucidated the potential mechanisms through which MIR17HG-miR-18a/19a axis induces GC invasive metastasis, and more importantly, we demonstrated that the role of MIR17HG in driving GC metastasis could be inhibited by IRF-1 (Fig. 8).