In contrast, Angptl2 and Cd68 expression in the media decreased 3 months post-infection, as did Pai-1, Il-1β and Mcp1. On one hand, this result suggests that Cd68+ macrophages express angptl2 and contribute to the local inflammation, as previously reported [29,32,40] and, on the other hand, that elimination of senescent angptl2+ EC reduced monocyte adhesion and macrophage infiltration. The gene discussed is SERPINE1; the disease is infection.