We have also shown that vascular ANGPTL2 expression is correlated with senescence and inflammatory cytokines of the SASP in pre-atherosclerotic internal mammary artery from patients with coronary artery disease, suggesting that angptl2 is a clinical marker of arterial senescence and that arterial senescence may precede plaque growth in human arteries. The gene discussed is ANGPTL2; the disease is coronary artery disorder.