Beyond the known benefits of eliminating senescent cells [18], the concomitant reduction both in the endothelium and the media of Pai-1, a well recognized SASP member and inducer of senescence [47], is clinically relevant: genetically driven high circulating levels of PAI-1 correlate with the severity of atherosclerosis [48], while conversely, a null mutation in its gene reduces markers of biological aging and increases longevity in humans [49]. Here, SERPINE1 is linked to atherosclerosis.