Next, we selected several EZH2 or LSD1 potential targets (P15, P21, KLF2, PTEN, TFPI2, LATS2, E-cadherin, and RND3) with tumor-suppressive role, and hypothesized that some of which may be associated with AGAP2-AS1-mediated carcinogenicity. This evidence concerns the gene EZH2 and neoplasm.