The finding that pressure-induced activation of Piezo1 disrupted the endothelial junctional barrier raises the possibility of targeting Piezo1 to prevent leaky lung microvessels and edema formation in conditions such as cardiogenic pulmonary edema, which is due to left heart failure, or hydrostatic pressure-induced breakdown of lung endothelial barrier associated with high altitude-induced pulmonary edema or head trauma (the Cushing response) (47). Here, PIEZO1 is linked to pulmonary edema.