SH2B1 and obesity due to melanocortin 4 receptor deficiency: Further experiments are needed to determine if these variants are the only functional variants at each locus, as we also observed allelic differences in protein binding for a second variant overlapping an ATAC-seq peak at the SH2B1 locus (Figure S5B) and others have suggested different functional variants at this locus,(Giuranna et al. 2018; Volckmar et al. 2012) and which gene(s) are contributing to obesity risk.