CD8A and urinary bladder neoplasm: It is intriguing to point out that in the control Ig–treated mice, in which MB49luc bladder tumor burdens increased during the 72–144-h time interval, CD4+ and CD8+ effector T cell numbers (Fig. 2d, e) actually increased, yet their activation status fell (Fig. 5a and b), providing additional evidence for immunosuppression.