Reduction in the number of MDSCs and macrophages following NHS-muIL12 targeting might also trigger a positive feedback loop wherein local IL-12 production supports IFN-γ accumulation [38]; this reignites the cytolytic abilities of resident CD4+ and CD8+ T cells leading to the significant regression seen in the MB49luc bladder tumors. Here, CD4 is linked to urinary bladder neoplasm.