ITGAM and urinary bladder neoplasm: In mice bearing MB49luc bladder tumors and treated with NHS-muIL12, the significant reduction of CD11b+ Gr-1+ MDSCs comprised both the Ly6C+ and Ly6G+ populations (Fig. 3a, b); the reduction in the CD11b+ Gr-1+ Ly6G+ cells (Fig. 3b) was more pronounced than that for the monocytic CD11b+ Gr-1+ Ly6C+ MDSCs (Fig. 3a).