In the present study, the immunosuppressive MB49luc bladder TME was further characterized by the presence of high numbers of myeloid-derived cells, primarily CD11b+Gr1+F4/80− MDSCs and CD11b+Gr1−F4/80+ macrophages as well as functional suppression of CD4+ and CD8+ T cell activation that underscored the inability of resident CD8+ T cells to control MB49luc bladder tumor growth. The gene discussed is ITGAM; the disease is urinary bladder neoplasm.