CD27 and chronic myelogenous leukemia, BCR-ABL1 positive: In a BCR/ABL-induced CML-like disease murine model, CD27 was expressed by LSCs (defined as Lin−Sac-1−c-Kithigh) and leukemia progenitors, where CD27 signaling enhanced proliferation and cell cycle progression in a Wnt/β-catenin-dependent manner [93].