The dysregulation of key genes related to the above pathways, including TGFβ2, LRP6, and TERT, was confirmed by RT-qPCR in CRC cells, although the expression of SMAD7 and HOXC5 was differentially regulated between CASC9-silenced HCT-116 and SW620 cells. The gene discussed is LRP6; the disease is colorectal carcinoma.