There were also close correlations between the expression in glomeruli and tubulointerstitium in AAV patients (r = 0.644, P < 0.001 for NOD2; r = 0.762, P < 0.001 for NLRP3; r = 0.844, P < 0.001 for NLRC5) (Fig. 2). The gene discussed is NOD2; the disease is anti-neutrophil cytoplasmic antibody-associated vasculitis.